sprague-dawley rats — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T0293	Metyrapone	NSC-25265,Su-4885	Others , P450 , Dehydrogenase , Autophagy
	Metyrapone (NSC-25265) is an inhibitor of the enzyme STEROID 11-BETA-MONOOXYGENASE. It is used as a test of the feedback hypothalamic-pituitary mechanism in the diagnosis of CUSHING SYNDROME.		Others , P450 , Dehydrogenase , Autophagy
T29112	VPC171	VPC 171,VPC-171	Adenosine Receptor
	VPC171 is a novel adenosine A1 receptor positive allosteric modulator (PAM).		Adenosine Receptor
T0031L	Ziprasidone hydrochloride	CP-88059 hydrochloride,CP-88059,Ziprasidone HCl	Dopamine Receptor , 5-HT Receptor , Adrenergic Receptor , Norepinephrine , Histamine Receptor
	Ziprasidone hydrochloride (CP-88059 hydrochloride) is a united 5-HT (serotonin) and dopamine receptor antagonist which shows potent effects of antipsychotic activity.
T34383L	2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv		Others
	2H-Naphth[2′,1′:4,5]indeno[1,2-d][1,3]dioxole, pregn-4-ene-3,20-dione deriv showed high local anti-inflammatory potency and high lung selectivity when tested on Sprague Dawley rats.		Others
T34949	Trimethylolpropane caprate	UNII-X307CM75YF,Trimethylolpropane tridecanoate,Trimethylolpropane tricaprate
	Trimethylolpropane caprate has developmental toxicity in Sprague-Dawley rats.
T37816	SB 243213
	SB 243213 is an orally active, selective and high-affinity 5-HT2C receptor antagonist with a pKi of 9.37 and a pKb of 9.8 for human 5-HT2C receptor. SB 243213 shows greater than a 100-fold selectivity over a wide range o...
TN1364	Ajugasterone C
	Ajugasterone C shows significant inhibitory effect at 100 mg/kg dose on rat paw oedema development due to carrageenan-induced inflammation in Sprague Dawley rats.
T61480	NHE3-IN-3
	NHE3-IN-3 (Compound 1) is a potent inhibitor of the isoform 3 of the Na+/H+ exchanger (NHE3). It exhibits pIC50 values of 6.2 and 6.6 against human and rat NHE3, respectively. Furthermore, NHE3-IN-3 showcases exceptional...
T36949	Niaprazine		5-HT Receptor , Adrenergic Receptor , Histamine Receptor
	Niaprazine is a histamine H1-receptor antagonist with marked sedative properties. Niaprazine has antihistamine and antiserotonin activities and can be used for sleep disorder research[1][2]. Niaprazine exhibits a low aff...		5-HT Receptor , Adrenergic Receptor , Histamine Receptor
T82886	Big endothelin-1 (rat 1-39)
	Big endothelin-1 (rat 1-39), a 39-residue peptide, induces a diuretic and natriuretic response in conscious Sprague-Dawley rats and elevates blood pressure in mice [1].
T64553	GLP-1(7-37) TFA salt
	The truncated glucagon-like peptides GLP-1(7-37) is naturally occurring peptide product of the preproglucagon gene that are synthesized primarily in the intestine and acts as incretin that are released from the intestine...
T71251	DS-1558
	DS-1558 is a potent and orally available GPR40 agonist.DS-1558 was found to have potent glucose lowering effects during an oral glucose tolerance test in ZDF rats. DS-1558 significantly and dose-dependently improved hyp...
T37585	Ensartinib
	Ensartinib (X-396) is a potent and dual ALK/MET inhibitor with IC50s of <0.4 nM and 0.74 nM, respectively. The ability of Ensartinib (X-396) to inhibit the growth of different cancer cell lines harboring ALK fusions or ...
T37096	Sepimostat dimethanesulfonate
	Sepimostat dimethanesulfonate (FUT-187), a chemical compound, demonstrates neuroprotective properties by antagonizing NR2B N-methyl-D-aspartate receptors at the NR2B subunit's Ifenprodil-binding site. This compound effec...